Molecular Insights into Development in Humans:Studies in Normal Development and Birth Defects Book PDF, ePub eBook

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Book Descriptions:

The aim and scope of this book is to review current information on human development and processes of differentiation that have benefited from breakthrough analyses in stem cell biology, elucidation of genome and gene architecture and aspects of regulation of gene expression, analysis of signaling systems and transcription factor actions.

Insights into actions of specific genes and their roles in development have been gathered through studies in patients with specific birth defects, including congenital malformations, metabolic defects and functional impairments.

The book is organized into three sections, the first dealing with aspects of genomics, gene structure and regulation, analysis of signaling and function of specific organelles. The second section deals with molecular aspects of development of specific organs and structures such as, bone, face, brain, heart, liver, pancreas, kidney. The last section deals with specific malformations and tumors that provide insight into regulation of growth. Environmental factors that impact growth and development are also covered.

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Contents:

• Genomes, Genes, Structure and Function
• Epigenetics
• Signaling Systems
• Pluripotency to Differentiation
• Development and Growth Abnormalities
• Metabolism and Organelles
• Brain Development
• Cranio–Facial Development and Defects
• Molecular Aspects of Heart Development
• Vasculogenesis Malformations and Hematopoiesis
• Abdominal Wall and Gastro-Intestinal Tract
• Lung and Diaphragm Development
• Liver and Pancreas Development
• Bone and Extra-Cellular Matrix
• Kidney and Urinary Tract Development, Malformations in Human Genes
• Sex Determination Differentiation and Endocrine Glands

Readership: Graduate students, physicians, geneticists, genetic counsellors and researchers in development biology.
Key Features:

• The concepts of receptor theory and hierarchical levels of pharmacological analysis are integrated and emphasised throughout the book
• Step-by-step instructions are given for the different types of pharmacological analyses

Molecular Insights into Development in Humans:Studies in Normal Development and Birth Defects by Moyra Smith

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